Endocrine Abstracts

In order to understand the mechanisms that underpin gonadal development, we have conducted a subtractive screen to identify transcripts expressed differentially during the sex-determining period. Suppression subtractive hybridization PCR was performed on cDNA derived from 12.5 dpc male and female gonadal ridges. Clones were tested for differential expression by RNA whole mount in situ hybridization. Those localizing to testis cords were further tested on germ cell-deple...

Seventy six-year-old man was referred to our hospital for examination of hypertension and hypokalemia. His blood pressure was uncontrolled although he was taking amlodipine besilate, spironolacton and candesartan. In addition, he suffered from atrial fibrillation and chronic heart failure. His serum potassium was low (2.8 mmol/l) and bilateral adrenal glands were found swelling. Hence, we investigated him thoroughly on the suspicion for primary aldosteronism.<p class="abst...

The testis and epididymis collaborate in the male gamete development. The testis has the specific function to generate spermatozoa and spermatozoa undergo numerous changes passing through the epididymis. p63 in the basal layer of epithelium plays a key role in maintaining cellular populations, whereas Notch 1 and its ligand Jagged 2 have an important role in the cell differentiation and Jagged 2 is up-regulated by TAp63, which transactivates p53 target genes and induces apopto...